Solate Plus is very important for women who are able to get pregnant. Plus When a woman has enough L-methylfolate in her body before and during pregnancy. It can prevent major birth defects including, spina bifida which occurs when an unborn baby’s spinal column does not close to protect the spinal cord. As a result, the nerves that control leg movements and other functions do not work. Children with spina bifida often have lifelong disabilities. They may also need many surgeries. Anencephaly which is when most or all of the brain does not develop. Babies with this problem die before or shortly after birth.